How does metformin help with gestational diabetes

Controversial: Metformin in pregnancy

Diabetes is one of the most common metabolic diseases. According to the Robert Koch Institute (RKI), around 4 percent of 18 to 39-year-old women in Germany suffer from type 2 diabetes. Thus, the disease also plays a role in women who want to have children. The so-called gestational diabetes must be considered separately in relation to the type of treatment. Unlike type 2 diabetes, gestational diabetes usually resolves after pregnancy. However, the temporary illness increases the risk of developing chronic type 2 diabetes later on.

Insufficient studies

Numerous studies and investigations with a large number of women are available on the use of metformin during pregnancy. However, the safety of the therapy is not fully understood. Over 1000 pregnancies showed no evidence of teratogenicity. According to the current state of knowledge, metformin also shows no foetotoxic properties. The drug has been well studied in all trimena. The three most common treatment indications during pregnancy include gestational diabetes, pre-existing diabetes, and polycystic ovary syndrome (PCOS). However, a large-scale subgroup analysis according to indication also showed that metformin can increase the risk of malformations, spontaneous abortions and premature births in existing type 2 diabetes.

Current study

Canadian scientists at the Canadian Institutes of Health Research (CIHR) have published the latest study results on metformin intake during pregnancy compared to placebo in the journal “Lancet Diabetes and Endocrinology”. The researchers examined the effects of adding metformin to standard insulin therapy. The scientists assumed that pregnant women were not adequately treated with either mono-insulin therapy or mono-metformin therapy. The randomized, controlled, double-blind, placebo-controlled study included 502 women. These were randomly divided into two groups. Only women with single pregnancies were included. Before the start of the study, the body mass index (BMI) was determined.