Mesothelioma can spread to the eye
Therapy of pleural mesothelioma
The treatment of pleural mesothelioma depends on the extent to which it has spread and the general condition of the patient. Interdisciplinary cooperation via the tumor board is essential and is guaranteed at the university hospital.
Pleural mesothelioma is a malignant tumor of the pleura. It usually develops over a twenty to forty year inflammatory process triggered by asbestos. After the Europe-wide ban on the mineral in 1990, a peak in the incidence of mesothelioma diseases is expected in the next few years. In contrast to most other types of cancer, pleural mesothelioma does not grow as a tumor at one point, but spreads over the entire pleura on one side of the chest and then spreads to the pleura.
If the tumor is still in its early stages, radical surgical removal is recommended. If the pleural mesothelioma is advanced, individually tailored measures that improve the quality of life and reduce the symptoms make more sense. This is done through a combination of chemotherapy, radiation, pain management and psychological care.
If there is a prospect of complete removal of the tumor, a pleuropneumectomy is performed in individual cases. In the open chest surgery, the entire pleura, lungs, pericardium and diaphragm are removed. This is preceded by neoadjuvant therapy to minimize cell spreading during the operation. Afterwards, a combined radiation and chemotherapy is planned again.
Pleurectomy and decortication
If the expansion of the lung is rigid due to tumor infestation of the lung membrane or is hindered by ingrowth, the complete removal of the lung membrane, decortication or pleurectomy, proves to be effective. Usually the diaphragm and pericardium are also removed, but the lungs are preserved.
Hyperthermic chemotherapy (HITHOC)
A relatively new procedure that is only offered at a few centers is the rinsing of the pleural cavity with heated cytostatics. Chemotherapy is performed locally immediately after the operation. The hot temperatures stimulate the metabolism of the cancer cells and the cell-killing substances are increasingly absorbed.
The repeated occurrence of pleural effusions in the pleural space can be stopped effectively and sustainably with a talc pleurodesis. The pleura are glued together from the inside so that no more fluid can accumulate in the space between them. In this way, the development of the lungs is no longer hindered and the symptoms of shortness of breath are significantly improved.
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